Teenager near Tokyo found to have Zika virus after return from Brazil

A male youngster near Tokyo become determined to had been inflamed with Zika virus after a go to to Brazil, Japan's first case of the contamination since the virus started spreading broadly in Latin the usa final 12 months, the health Ministry stated on Thursday.

the man stayed in Brazil for 12 days via Feb. 20 and ran a fever on his final day. He also came out in a rash a few days after his return, however is now in a strong circumstance without a fever and is resting at home, the ministry said.

"Japan for the time being isn't in a season whilst mosquitoes are lively. danger of infection spreading is extremely low," the ministry said in a statement.

the person in Kanagawa prefecture, southwest of the japanese capital, is the fourth case of Zika virus infection in Japan. three eastern were located wonderful in 2013 and 2014 after getting back from French Polynesia and Thailand.

lots stays unknown approximately Zika, inclusive of whether or not the virus in reality causes microcephaly.

Brazil is investigating the capability link between Zika infections and greater than 4,000 suspected cases of microcephaly, a circumstance marked with the aid of abnormally small head size that may result in developmental issues.

Flavonoids in fruits and veggies might also assist combat weight gain with age

consuming masses of end result and greens rich in flavonoid molecules may assist adults decrease weight gain as they age, a latest take a look at shows.

maximum vegetation contain different flavonoids in various concentrations. some scientists trust these obviously occurring compounds have antioxidant and anti-inflammatory properties that could assist explain some of the health benefits associated with diets wealthy in culmination and veggies.

"We found that multiplied consumption of fruits like apples, berries and grapes was related to less weight gain and those are high sources of a few varieties of flavonoids," stated lead study creator Monica Bertoia of Harvard T.H. Chan faculty of Public fitness in Boston.

not all kinds of flavonoids, however, have been linked to reduced weight advantage as soon as researchers accounted for a way lots fiber people ate, Bertoia introduced by means of e-mail.

"The purpose of this studies is to determine which fruits and greens can be quality for weight protection so as to refine dietary recommendations that presently suggest ingesting extra end result and veggies however don't absolutely specify which end result and veggies are better than others for the prevention of weight problems," Bertoia stated.

To have a look at the connection among flavonoids and weight, Bertoia and colleagues analyzed survey information on about 124,000 U.S. fitness experts collected among 1986 and 2011.

They excluded human beings with continual diseases and folks that have been overweight at the start of the surveys, and additionally temporarily dropped data on girls after they had been pregnant.

contributors mentioned their weight each two years and finished nutritional questionnaires each four years.

based totally on what people stated they ate, researchers used U.S. branch of Agriculture information on flavonoid content in particular ingredients to determine how plenty of these compounds contributors consumed.

throughout all the studies, half of the contributors fed on at least 224 milligrams to 247 milligrams of flavonoids an afternoon.

Over each 4 12 months period, people gained an average of two.2 to 4.four kilos.

however human beings with higher than common flavonoid consumption tended to benefit barely much less weight, researchers document in the BMJ.

The distinction amounted to approximately one-10th to a few-fifths of a pound over 4 years for every general deviation above the common quantity of flavonoid consumption.

as an example, consuming 7 milligrams greater flavonols - a subtype of flavonoids observed in tea and onions - than average each day was related to gaining kind of one-6th of a pound much less weight over 4 years.

To degree the effect of all flavonoids, researchers adjusted for a extensive range of factors that could have an impact on weight along with age, gender, exercising, smoking, alcohol, caffeine, sleep and sedentary television time. in addition they accounted for different things people ate up, together with juices, fried foods, complete as opposed to refined grains, full-fat as opposed to low-fats dairy, sodas, processed versus non-processed meats, trans fats and seafood.

After adjusting for fiber consumption, which may impact weight benefit by decreasing how much fats people soak up, handiest 3 varieties of flavonoids have been related to decreased weight benefit within the look at – anthocyanins, which came mainly from blueberries and strawberries in participants’ each day diets; flavonols and flavonoid polymers, which got here normally from tea and apples.

different obstacles of the take a look at include its reliance on survey participants to correctly file what they ate and what sort of they weighed, the researchers be aware. food questionnaires used in the surveys also won't have captured every nutritional supply of flavonoids.

nevertheless, the findings advise that selecting excessive flavonoid culmination and veggies including apples, pears, berries and peppers might also assist with weight manage, the authors conclude.

it's also possible, however, that those who consume more fruits and greens may have an simpler time with weight management due to the fact they consume a more healthy diet and eat fewer calories, mentioned Samantha Heller, a registered dietician and workout physiologist affiliated with the big apple university Langone clinical middle in ny metropolis.

"while we frontload our food plan with plant primarily based foods inclusive of berries and peppers, we crowd out much less healthy options like French fries and burgers," Heller, who wasn't involved within the observe, stated via e-mail. "it can additionally be that those humans are greater health aware than others."

Researchers with opposing views on salt consumption are ignoring each different

at the query of whether the populace would advantage if human beings cut again on salt, researchers fall into two camps, consistent with a new file.

at the same time as maximum research have concluded that cutting salt could have blessings, approximately a 3rd do not agree. And researchers on each aspects of the difficulty tend not to take the alternative aspect’s findings into consideration.

“we've no longer analyzed why there is a divide, we will handiest suggest or make assumptions after the fact,” stated Ludovic Trinquart, the lead writer of the new document and a Columbia college Epidemiology benefit Fellow at the Mailman school of Public health in big apple town.

Trinquart and co-workers reviewed 269 number one research, analyses, medical hints, consensus statements, remarks and letters on salt intake and health posted between 1979 and 2014. They taken care of the papers primarily based on whether or not or now not they supported the hyperlink between decreased sodium intake and decrease prices of coronary heart disorder, stroke, and dying.

They discovered that fifty four percent of papers supported the hypothesis, 33 percent refuted it, and thirteen percentage had been inconclusive.

people who supported the hypothesis tended to cite other papers that supported it, too, even as people who refuted tended to cite others that refuted also, with little crossover between the camps.

As mentioned in the global journal of Epidemiology, Trinquart’s team located 10 systematic opinions that pooled the information from a total of forty eight number one studies - but every evaluate did now not always encompass all to be had research. choosing which number one research to cite motivated the conclusion of systematic critiques, the authors discovered.

“One facet preferentially cites preceding papers that determined a similar conclusion,” Trinquart instructed Reuters fitness by way of telephone.

His very own have a look at can not provide any man or woman or populace-stage advice on real salt intake, he said.

“On the one side, there is powerful bias by way of the salt industry,” said John P.A. Ioannidis of the Stanford Prevention studies center, who wrote a remark at the observe. “On the alternative aspect, there may be additionally bias from teachers who want to defend their theories.”

there's consensus that salt intake needs to be decreased, however by way of how a whole lot remains up for debate, Ioannidis informed Reuters health by means of e mail.

“i'm a proponent of the concept that salt is terrible for you,” said Bruce Neal of the George Institute for worldwide fitness in Sydney, Australia, who wrote another of the three commentaries accompanying the look at. “nearly all people is ingesting extra than they absolutely require.”

we will research greater from considering have a look at exceptional instead of simply sorting all studies into two camps, Neal informed Reuters fitness via cellphone.

“a variety of the talk is around vulnerable research,” he stated.

national and worldwide tips from establishments like the global fitness employer unanimously advocate salt discount, he said.

“We lack a huge definitive randomized trial that shows that reduced salt protects towards coronary heart assault, however there may be little or no evidence that reduced salt might do damage,” Neal said.

these days adults consume a mean of 10 grams of salt consistent with day, but any greater than  grams a day and the kidneys “are just seeking to pee out as tons salt as they can,” he said.

“There’s excellent proof that if you devour too much salt it pushes up your blood strain,” he stated.

research that refute this hypothesis divide people by means of how plenty salt they're already ingesting, however those who eat little or no salt may have already had a coronary heart attack or stroke or may have terminal stage cancer, so their worse health outcomes have other underlying causes, he said.

“The big majority of folks who work in scientific medicinal drug say it's miles much more likely that salt is terrible for you than excellent for you,” Neal said.

Zika outbreak will worsen earlier than it gets higher with the aid of Stephen Eisenhammer

the head of the arena fitness agency warned Wednesday that the Zika outbreak would likely worsen before nations besieged by means of the mosquito-borne virus related to heaps of beginning defects in Brazil see comfort.

Director-general Margaret Chan made the comments on the cease of her two-day go to to Brazil, the u . s . a . at the epicenter of the Zika crisis.

"things may additionally get worse earlier than they get higher," Chan stated at a information convention in Rio de Janeiro. "do not be surprised to see microcephaly suggested in different elements of Brazil."

As but, Brazil's Zika outbreak has been focused in the northeastern a part of the state.

lots remains unknown approximately Zika, consisting of whether the virus really reasons microcephaly, a condition marked by surprisingly small heads which could result in developmental issues. Chan underscored that scientists are still running to determine causality among the virus and the start defect.

Brazil said this week it has confirmed more than 580 instances of microcephaly, and considers most of them to be associated with Zika infections within the mothers. Brazil is investigating extra than four,a hundred additional suspected cases of microcephaly.

After Brazil, Colombia has been hardest hit via Zika infections with the united states's health officials reporting on Wednesday a likely case of microcephaly possibly linked to Zika in an aborted fetus.

Colombia has suggested more than 37,000 instances of Zika which includes 6,356 in pregnant women however has yet to have a confirmed microcephaly case related to the virus. as a minimum 34 countries, basically in the Americas, have energetic Zika outbreaks and the virus is anticipated to spread.

the arena health employer declared the outbreak an global health emergency on Feb. 1, mentioning a "strongly suspected" dating among Zika contamination in pregnancy and microcephaly. Scientists also are reading a ability link between Zika infection and Guillain-Barre, a unprecedented neurological disorder which could weaken the muscles and cause paralysis.

AstraZeneca's $4 billion Acerta deal encouraged by way of orphan drug popularity

AstraZeneca's (AZN.L) bold move to buy 55 percentage of privately held biotech firm Acerta Pharma for $4 billion in December has been vindicated, at least in element, with the aid of the award of unique "orphan" popularity to the important thing experimental drug worried.

The drugmaker stated on Thursday that the eu medicines enterprise had recommended acalabrutinib as an orphan product for continual lymphocytic leukaemia or small lymphocytic lymphoma, mantle cell lymphoma and lymphoplasmacytic lymphoma.

Orphan status is awarded to drug treatments promising tremendous benefit within the treatment of uncommon, lifestyles-threatening illnesses and the designation affords agencies with unique development and marketplace exclusivity incentives.

AstraZeneca offered manipulate of Acerta to get its arms on acalabrutinib, which it believes should generate sales of greater than $5 billion a yr. The drug is presently in the very last tiers of scientific development for numerous blood cancers.

Acalabrutinib works in a comparable way to AbbVie (ABBV.N) and Johnson & Johnson's (JNJ.N) Imbruvica. but AstraZeneca reckons it has fewer facet consequences than Imbruvica and potentially higher efficacy. Rival drugs are in addition at the back of in improvement.

Acerta shareholders will have the option to promote the last 45 percentage of stocks in the biotech business enterprise to AstraZeneca for about $three billion once acalabrutinib has been authorized in each the us and Europe.

the new medicine is a so-referred to as Burton's tyrosine kinase inhibitor that objectives an array of blood cancers and doubtlessly some strong tumors. it can also help in autoimmune sicknesses such as rheumatoid arthritis and lupus.